Of course you know as well as I do that there is a literal mountain of products out there, all of which supposedly give you the anti aging wrinkle results you so desperately desire. If you’re well read however then you know all too well that most anti aging products barely do anything!

The fancy marketing presentations (aka ‘lies’ and ‘mis-truths’) that manufacturers come up with to ‘spin’ their products are designed to mis-lead you and tell you what you want to hear. They also cleverly hide any and all weaknesses that each product contains. But, their days of basking in the vast profits that amass from consumers lack of knowledge are fast coming to an end!

Over the past 10 years researchers have been hard at work learning what actually works and why. So, let’s just cut to the chase!

When it comes to anti aging wrinkle cures what works and what doesn’t work? And just how many ‘PROVEN” anti aging wrinkle substances actually exist?

Well, according to a recent review in The Archives of Dermatology, there are THREE treatments out there waiting for you which are “proven clinically effective”!

1. The topical application of retinol


2. Carbon dioxide laser resurfacing


3. An injection of hyaluronic acid

WOW – only three!

Each of these treatments work with the same mechanism of action- the interaction of connective tissue cells (called ‘fibroblasts’) with the collagen they produce.

David Leffell, a professor of dermatology and surgery at Yale, said in response to the study “This is an area where there’s a lot of hype and not much substance”

Of course any of us who have spent a small fortune on anti aging wrinkle creams and serums over the years already know this.

Leffell went on to say that this particular study is “good science”.

What researchers have come to gradually recognize is that the cause of wrinkles lies with damage to the mechanical properties of collagen outside your skin cells, and not necessarily genetic damage to the cells themselves. This discovery sits along side an improved understanding of ‘dermal collagen’ which is your skin’s connective tissue.

So, here’s an easy breakdown.

Fibroblasts create collagen. So, in a perfect world they could go on their merry way unimpeded throughout our lives busily making collagen to keep us looking young. But…..

…of course there’s always a ‘but’ and here it is. Exposure to sunlight diminishes fibroblasts ability to produce collagen!

Which body parts receive the greatest sun exposure? That’s right, your face, neck, hands and upper chest. All the areas where we wrinkle the most (and don’t want to). This connection is clearly demonstrated in fair skinned people whose light-pigmented skin wrinkles more readily than darker skinned people.

You know that your skin naturally deteriorates with age. This is in part because certain enzymes degrade your collagen. But ultraviolet radiation from sunlight sets of the production of these same enzymes. Double whammy! Sun damage to your collagen and its production essentially creates a situation representing accelerated natural chronological aging.

So, with age and exposure to ultraviolet radiation, your collagen fibers deteriorate and fragment. This inhibits the fibroblasts collagen producing ability. As the fragmented collagen accumulates, new collagen production declines, the connections between the fibroblasts and the collagen weaken, and the skin, now lacking support, begins to wrinkle!

Anti Aging Wrinkle Magic

Enter our three proven treatments from above. Each one is able to tackle this destructive process.

Retinol ( a form of vitamin A) when applied topically on your skin causes the production of new collagen in both naturally aged skin and skin damaged by ultraviolet radiation.

How does it do that? Well no-one is really sure, The molecular pathways involved are not very well understood as yet. But as long as we know it works then who really wants to know how it performs its anti aging wrinkle magic.

The next logical question is what concentration of retinol is enough to have an effect?

According to Dr, Gary J. Fisher, a professor of dermatology and the lead author of the review, you should look for concentrations of 0.2% to 0.6%

Strangely enough MANY of the retinol containing skin creams which are available over the counter do not list the concentration of the retinol. Only a company with something to hide would resort to such measures so steer clear of these kind of dubious products.

A totally ineffective concentration of say 0.005% still qualifies a manufacturer to market their retinol wonder product in big bold letters! These incredibly tiny concentrations barely qualify the retinol as the active ingredient! They are simply a waste of money.

And don’t be sucked in by useless products that do state the concentration of retinol on the label. Take careful note of that number!

Now, with over the counter retinol products there is a fine line between effectiveness and side effects! Anti aging wrinkle preparations with retinol concentrations strong enough (as above) to produce results can cause a ‘retinoid dermatitis’. In such cases you must stop using the product. A gradual build-up in concentration has proven effective for some in avoiding this problem.

Retinol also makes your skin more prone to ultraviolet light damage. Strict sun protection measures such as umbrellas or avoiding the sun altogether are absolutely crucial while using retinol.

If you take your anti aging wrinkle strategy very seriously then the best bet is to go for a prescription strength retinol preparation rather than risking an over the counter product.

Anti Aging Wrinkle Strategy – Zap Them

Now we come to the second treatment from our ‘effectiveness proven’ list – carbon dioxide laser resurfacing.

This CO2 laser has been around for quite a while now and it’s effectiveness has been well tested. I definitely know this treatment works because I’ve had it done on my face twice in the past 12 years and my results were nothing short of fantastic. For most people though one treatment in a space of this many years would normally be enough. (When it comes to my anti aging wrinkle program I’m a bit on the ‘intense’ side!)

If you’re not familiar with the CO2 laser, what it does is to burn away very fine layers of skin without damaging surrounding tissue. New collagen is produced as the wound heals.

The healing time takes on average 2-3 weeks. This rather long recovery period is what turns many people away from this treatment option. You need to completely avoid the sun while your skin is healing.

There are several alternative lasers available now which have virtually no recovery downtime but the results are way less noticeable than with the carbon dioxide laser, as far as I’m concerned. I’ve tried one of these lasers (around my eyes) roughly 1 year ago and frankly I felt that that the financial outlay was just not worth it for the minimal results achieved. Particularly because I had experienced the results of the CO2 laser earlier so it was easy to assess the comparative effectiveness of both treatments.

Anti Aging Wrinkle Injections

Injections of a form of hyaluronic acid, similar to a substance the skin normally produces, into the dermis that underlies the wrinkles is the third and last of our three effective anti wrinkle treatments.

The interesting thing with hyaluronic acid is that it was originally used as a space filler to ‘fill in’ wrinkles. There was no intended physiological outcome.

In time researchers discovered that as the injection stretches the dermis, fibroblasts react by increasing their collagen production levels. The authors of the Archives of Dermatology review cite studies that have demonstrated that increased collagen production is visible within a month after the injection. The benefit lasts about six months, Dr. Fisher said.

You’ll find topical creams containing “Hyaluronic Acid” for sale but this form is not the same as the effective injectable form. It is not possible to stimulate new collagen with these topical skin preparations so please don’t waste your money on any of them.

Anti Aging Wrinkle Cures – Specialized Nutrients

We’ve seen that these three treatments effectively address the reduction of wrinkles and are backed by solid research. But there’s more we can add to create a much more potent anti aging wrinkle program!

You can address your wrinkles from the inside out!

What I mean by this is using cutting edge nutritional science to address the primary causes of chronological aging. This involves sophisticated supplementation with specialized nutrients that can tackle the four fundamental causes of aging.

Do you know what these four ‘aging components’ are?

1. Free Radical Production


2. Glycation


3. Methylation


4. Inflammation

Each of these is a traumatic and highly destructive situation for your health. But all four together represent a colossal tidal wave of health issues and degenerative disease. You see they are all interrelated so you must tackle all four at the same time.

Living in the civilized world of the 21 st century is the chief cause of these four health busting conditions. Their net effect on your health is PREMATURE AGING. This means the greatest majority of people living in the modern civilized world are aging far faster than what mother nature intended.

Besides the onset of degenerative disease, premature aging leads to the degradation of your collagen. Remember I mentioned earlier how your skin naturally deteriorates with age? Well, premature aging speeds that process up tremendously. Basically your collagen begins to collapse and those youth destroying wrinkles appear more and more.

So, as far as your anti aging wrinkle program is concerned, for more powerful results you need a 2 pronged approach. The first is addressing wrinkles at the skin level with the one of the proven treatments from above. The second is to address premature aging by using supplements containing proven nutrients which can take on and deal with free radicals, glycation, methylation and chronic inflammation.

Perhaps you may like to read my anti aging secrets and nutritional supplements series There are four parts and each part covers one of these four aging components and reveals the names of the specialized nutrients needed to tackle it. Parts 1-3 are available now and the final article will be out next week. Just use the link above to pop over to Part 1.

Some of these special ingredients are extremely rare in the nutritional supplement industry. In fact, there is only one multi ingredient health/vitamin supplement in the entire market that contains ALL of them to successfully address premature aging by slowing down and normalizing your chronological aging process.

How do I know?

I used to work in the supplement industry and I’ve reviewed hundreds of supplements including the markets leaders. I can tell you that almost all nutritional health supplements (or nutritional vitamin supplements as they’re more commonly called) address free radical production through the use of antioxidants. But as for the other three primary causes of aging, manufacturers simply cannot afford to include the specialized ingredients that can get the job done. That’s because almost all of them set out to manufacture their supplements to a price!

This approach guarantees that they will NOT include all the necessary key ingredients that the latest nutritional science has identified as the most potent and effective!

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Click on this link if you would like to know more about the only nutritional supplement that includes all the specialized ingredients to tackle free radicals, glycation , methylation and inflammation. There’s separate versions for males and females.

And if you would like to read my review of this supplement (it’s called Total Balance) use this link here: Total balance review

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In Part 1 of this anti aging secrets and nutritional supplements series I looked at the meaning of anti aging in respect of nutritional supplements. This, I stated, was the ability of nutritional health/vitamin supplements to tackle the number 1 most prevalent health concern of the 21 st century – PREMATURE AGING.

Premature aging is responsible for the host of degenerative diseases and illness’ which are inflicting an ever-increasing percentage of the population at younger and younger ages! The stats are climbing year in year out and I’m sure you’re all too aware of this health-devastating trend.

You only have to think about how many people die these days of a disease! That’s NOT how mother nature planned for us to go out!

So, the ‘[tag-tec]anti aging[/tag-tec]‘ capabilities of [tag-ice]nutritional health supplements[/tag-tec] must not only be able to correct [tag-tec]vitamin[/tag-tec]/mineral deficiencies (the simplest common denominator for all of them) and then also be able to help heal degenerative [tag-ice]disease[/tag-ice] which may already be present, but MOST importantly be able to comprehensively address the causes of premature aging in order to slow down and normalize (to some significant degree) the aging process, thereby addressing the spiraling increase in degenerative disease in western diet based societies

I went on to say that virtually all nutritional vitamin supplements FAIL when it comes to addressing premature aging!

Why?

Because there are four primary components of aging and each of these is interdependent on the other three. So, to successfully address premature aging a supplement must contain specialized ingredients which can adequately tackle ALL FOUR.

But….

…. just about any nutritional health supplement you care to examine, including the most well known and ‘so-called’ elite super supplements, can only take on ONE of these four key aging components – which is the reduction of free radicals through the use of antioxidants. (For MANY supplements it’s primarily by way of the cheap, less potent vitamin antioxidants only).

The other 3 critical aging components which are not addressed are Glycation, Methylation and Inflammation because the specialized ingredients needed to deal with them are simply not there!

I then ‘opened up’ for discussion the first ‘anti aging secret’ – the role of free radicals in our aging process and I revealed the names of the most powerful and effective antioxidants which neutralize them (the antioxidants that most supplements can’t afford to include!)

If you haven’t yet read Part 1 and would like to, just follow this link anti aging secrets and nutritional supplements part 1

Today, I will continue on by looking at Glycation and exposing what specialized ingredients MUST be there (but nearly always aren’t) to tackle this SERIOUS health crippling process.

Anti Aging Secrets – Glycation leads to AGES And AGES AGE US!

Oxidative damage to your cellular DNA from excessive free radical production in your body is a SERIOUS problem for your health and wellness but Glycation is far more destructive!

So, if you’re conscientious about good health it’s VERY important that you understand how to protect yourself from glycation.

Glycation is a complex process so bear with me while I first spend a little time explaining it (as simply as I can) before revealing the names of those ‘ANTI GLYCATING INGREDIENTS that I’m sure you want to know asap!

The glycation process revolves around protein molecules in your body and basically alters/damages their configuration so they are unable to function correctly.

This is REALLY BAD NEWS for your health because your various types of proteins have key responsibilities in performing biological activities throughout your body which are critical to your health.

So, in a nutshell, glycation is a (non-enzymatic) reaction through which glucose molecules and chemicals derived from glucose, known as ‘aldehydes’ (collectively we can call them all ‘glycating agents’ for ease of understanding), bind themselves to your intra- and extracellular protein molecules. ie. the protein molecules have become ‘glycated’!

Glycated proteins are no longer ‘free agents’ able to effectively perform their designated biological duties necessary to guard against premature aging.

GLYCATED PROTEINS ARE RELIABLE MARKERS OF DISEASE AND AGING!

The new structures formed by glycated proteins are called AGEs which stands for Advanced Glycation End-products. These are REALLY DANGEROUS molecules when it comes to your health!

When both of the sticky ends of AGEs attach to other neighboring proteins, they create permanent, disabling links.

Anti Aging Secrets: Cross-Linking And YOUR Wrinkles

This process of inappropriate attachment is called ‘cross-linking’. You’ve probably heard this term ‘cross-linking’ before.

Cross-linked chains of AGES decreases the mobility/elasticity of proteins. Cross-linking of the skin protein ‘collagen’ has been shown to be responsible for wrinkling and other age-related changes in skin. So, if you take in a lot of sugar through you diet you’re going to have more glucose molecules floating around inside you and that means more glycation, leading to the collapse of more collagen and so MORE WRINKLES.

AGES normally form and accumulate at a slow and steady rate in everybody (except those with diabetes where the greatly increased availability of glucose leads to a marked increase in their formation earlier in life).

But, AGES do a lot more health-busting damage than just playing a part in creating wrinkles.

They produce poisonous chemicals and toxic by-products as well as stimulating free radical production leading to further glycation – a vicious cycle endures! Glycated proteins increase free radical production 50 fold (over non-glycated proteins).

Remember how I mentioned in Part 1 that each of the 4 primary aging components were interdependent? See how they work together?

Researchers have also implicated glycation to Alzheimer’s disease!

And there’s more! Glycation contributes to HEART DISEASE. It thickens artery walls and clinical evidence suggests that AGEs are important components in the formation of potentially lethal atherosclerotic plaque – that’s the stuff that can build up to impede and block blood flow in your arteries.

So, you’ve no doubt got the picture by now of how destructive glycation is to your health. You absolutely need to take action to limit the amount of glycation and formation of AGES in you body. This is a VITAL STEP in slowing down and normalizing your aging process.

What to do!

1. GREATLY reduce the intake of sugar in your diet. Learn the ‘hidden’ sugar content of what you are eating. Avoid simple carbohydrates!

 

2. Inactivate the glycating agents (aldehydes) before they can bind to your proteins

 

3. Prevent a glycated protein from binding to another ‘free’ protein and creating a cross-linked chain

You’re wondering what to do for steps 2 and 3, right?

Well, you can achieve that through ‘Carnosinylation’!

Huh?

A clever and powerful nutrient called Carnosine (an amino acid) is capable of defending your body’s proteins against glycation. The process by which carnosine does this is called carnosinylation.

Inhibiting The Formation Of AGES Is An ESSENTIAL Part Of Any SUCCESSFUL Anti Aging And Life Extension Program!

Here’s what carnosine actually does!

1. It can bind itself to glycating agents and NEUTRALIZE them

2. And it can put a shield around a protein molecule which already has a glycating agent attached. This protects and prevents it from cross-linking with another protein

NO OTHER NUTRIENT CAN DO THIS!

Oh, and carnosine stops the oxidative damage of free radicals!

If you go and check your supplement label I bet you won’t find carnosine listed there. That’s because it’s a very expensive ingredient for nutritional supplement manufacturers to purchase. They simply can’t afford to include it. So, once again we come back to the greatest limitation in the formulation (and effectiveness) of nutritional vitamin supplements – that they are made to a price!

This is why supplement companies (deliberately) fail to mention glycation on their websites or in their product marketing presentations. They don’t want to highlight a major weakness in their product!

Anti Aging Secrets: How Much Carnosine?

“Like so many nutrients there is no real evidence to support the premise ‘more is better’“

The generally accepted effective dose rate is 50 – 150 mg daily!

The multi ingredient health supplement my family and I have used for the past 7 years is called Total Balance and it includes a generous dose of 100 mg of carnosine in a daily dose. (That’s one of the main reasons I originally opted to use it.)

Use these links to take a look at total balance mens plus or total balance womens plus

Or follow this link if you’d like to read my in-depth review of total balance (It’s a loooong one!)

Now, some of you may be thinking right about now about racing out to buy a bottle of isolated carnosine. Don’t do that.

Carnosine, like most specialty nutrients, works FAR more effectively when combined with other compatible ingredients (that’s why you need a professional grade supplement formulated by a bio-scientist or chemist because only they know what nutrients are compatible with one another at the molecular level in your body to synergize enhanced efficacy).

Supplements put together by physicians and worse still by marketers, don’t even come close to making the grade!

And , as you’ve discovered, glycation is only one of the four (interdependent) primary components of aging. There’s not much point in addressing only glycation at the expense of the other 3.

Anti aging secrets special note:

There are currently some really promising experimental drugs being tested to fight AGES – but sorry you’ll have to wait a while. None are yet commercially available. If and when any do become available I’ll be sure to make a post about it.

In the next part of this anti aging secrets series I’ll discuss the third aging component, METHYLATION, and give you a heads-up on the special methylation agents you need in your vitamin supplement to combat it.

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