1. Free Radical Production
2. Glycation
3. Methylation

and how to effectively treat them with specialized and in some cases rare supplement ingredients.

Your body has to fight against these SERIOUS problems every single day. Besides aging you they are responsible for the onset of degenerative disease.

These four aging components require specialized ingredients in your nutritional health supplement to effectively address and control them.

The problem we have seen however is that because around 99% of vitamin health supplements, of all standards, are manufactured to a price, with many distributed via expense heavy MLM structures, these specialized ingredients are just too expensive to be included.

In today’s article I will look at the final aging component – Chronic Inflammation.

When people hear the word ‘Inflammation’ most will immediately think of Fish Oil and Omega 3. Yes, you will see Fish oil in the list below of the necessary specialized anti inflammation nutrients but……………

It Takes Much More Than Fish Oil To Adequately Tackle And Control Inflammation!

If inflammation is not controlled it will cause crisis to your health!

It is a serious condition but one that is not mentioned much in anti aging discussions. In fact there are leading scientists who have publicly stated that chronic inflammation is the main contributor to age related health damage. This is because excessive inflammation causes toxic chemicals which eat away body tissues, thus leading to heart disease, dementia, arthritis and diabetes and so on.

Just think about that for a moment!

Regardless of whether these scientists are spot on or not chronic Inflammation is a VERY BIG DEAL when it comes to your health and to the issue of

PREMATURE AGING!

You see, just about every one of us is suffering from premature aging. That’s because we live in the civilized world and so we can’t hide from the causes:

Things like oxidation (from breathing), X rays, sunlight, and numerous dietary/environmental toxins and stressors which impact on our health EVERY SINGLE DAY! (The only way to escape these is to run away and live in remote places like the Himalaya’s, with races like the Hunsa’s who live to around 120 years and where men father children well into their nineties.)

How do these things impact your health exactly ?

The answer is above!

They SPEED UP the four things which are primarily causing you to age: Free Radical Production, Glycation, Methylation and Inflammation.

So, to support, improve and (hopefully) optimize your health, you need to SLOW DOWN AND NORMALIZE YOUR AGING PROCESS . In other words to bring it more into line with what mother nature intended.

Therefore you must comprehensively take action against free radical, glycation, methylation and inflammation.

That’s the straightforward answer you’ve been looking for.

Anti Aging Secrets – Take Action How?

Well, your dietary intake is certainly a HUGE part of the action you must take but as you have/will discover from my previous articles in this series, some of the specialized anti aging nutrients you must have to take on free radicals, glycation, methylation and inflammation, cannot be taken in through your diet.

That’s why supplementation is so critical to the process.

So, if you believe in using nutritional health supplements, and you are/are going to spend good money on one, on a continuing basis, then you absolutely need to make sure it can do more than just top up any nutrient deficiencies you may have!

The key here is to understand that these four components are completely interrelated. That means you have to treat all four simultaneously. It’s completely a waste of time buying an isolated nutrient(s) in order to address just one or two of them. This WON’T WORK.

If you haven’t read through parts 1,2 and 3 of this anti aging secrets series then this might be a good time to do so and then you will understand the interconnection of these four aging components. (Use the anti aging secrets links in the sidebar over on the right of this page.)

But here’s a good example to highlight this interrelatedness.

MDA (Malondialdehyde) is a dangerous chemical byproduct formed in your body as a result of the action of free radicals on the fatty membranes of your cells. It is a major factor in the production of AGEs from glycation. This same chemical, MDA, is also involved in inflammation.

Anti Aging Secrets – Reduce The Summation

So, if you try using anti-oxidants to decrease your free radical population then you will reduce the oxidation of your cell membranes which will in turn reduce the formation of MDA which in turn will reduce glycation and thereby the creation of AGEs. Presto- you have reduced inflammation as well!

But you still need to take Carnosine (part 2) in addition to the most powerful antioxidants (part 1) to inhibit the creation of AGEs because there will still be free radical production – you can’t kill all those troublesome free radicals – so MDA is still going to form and try to create AGEs which in a summation effect will contribute to inflammation

And you can’t stop the production of all AGEs and by connection not all inflammation can be avoided so you absolutely have to use specialized nutrients that can tackle inflammation (in ADDITION to the the other specialized nutrients for glycation, methylation and free radicals. (parts 1, 2, 3)

In part two, I discussed the unique qualities of the nutrient ‘Carnosine’ with respect to glycation. Well, Carnosine is also on the list of specialized ingredients for addressing inflammation. Carnosine really is an amazing nutrient!

One nasty component of inflammation is excitotoxicity. This is a process which leads to damage and death of nerve cells from excess levels of glutamate and similar substances in your diet (MSG and other flavor enhancers, like aspartame, are the problem – take note! ) If brain cells are killed due to excitotoxicity this can lead to strokes, traumatic brain injury and neurodegenerative diseases like Multiple sclerosis and Alzheimer’s disease.

One of the very dangerous chemicals associated with chronic inflammation is Tumour Necrosis Factor (TNF). TNF actively promotes the degeneration of your brain and nerves! It is activated by a combination of free radicals and AGEs.

A supplement label SHOULD list the category of nutrients it contains, like Vitamins, Herbal Extracts, Enzymes, Amino Acids, Immunity and so on? An important category of nutrients that should be on that list is ‘Calorie Restriction Mimics’. Is it there on your supplement label?

To keep the production of TNF as low as possible you need to take in the best known calorie restriction mimic:

Resveratrol.

For greater efficacy and increased value for money be sure to check that any Resveratrol in your supplement is in the ‘Trans’ form and not the cheaper and less bioavailable ‘Cis’ form! Due to resveratrol’s extremely high price, supplements that can afford to include it usually do so with very low potencies of around 5 – 10% and inadequate dose amounts (< 50 mg). BEWARE!

And speaking of well known, let’s talk about Omega 3 fish oil. Now, most doctors and health experts promote fish oil exclusively as the answer to inflammation. There’s no debate that the anti inflammatory activity of fish oil helps significantly in controlling inflammation but the problem here is that it addresses only one component of the much wider picture of inflammation.

So to finish up, here’s your list of the most effective anti-inflammation nutrients that work in synergy with fish oil in addressing and reducing inflammation:

• Resveratrol

• Glutathione

• Carnosine

• Turmeric

• Alpha Lipoic Acid

• Flavanoids

Anti Aging Secrets- Summing Up

I’m sure many of you reading this article would now like to expand your anti aging knowledge more. So, just let me give you a heads up that a very large amount of the literature out there promotes just free radicals as the most important concern in anti aging programs.

Of course you know this is NOT the case. Supplement companies and marketers are responsible for this – because their products do not address glycation, methylation and inflammation, they won’t mention them. They also have tried to brain wash consumers into believing that fish oil is the sole answer for inflammation.

But…just using antioxidants to tackle free radicals or fish oil for inflammation, will NOT achieve what you want. It is only PART of the complex anti-aging equation.

Well everyone, that wraps up this anti aging secrets and nutritional supplements series. I hope it has helped you to understand your aging process more fully and the actions you need to take to comprehensively tackle and protect yourself from the serious health issues that speed up your aging and lead to degenerative disease and a debilitated lifestyle.

Nature intended for us to live in vibrant health and die from natural causes – not from disease. But unfortunately that’s not the case for the majority of the population today.

We all really do need a helping hand from the best nutritional health supplements to make this possible.

Here’s one more heads up for you. I review hundreds of supplements each year including the so called market leaders. To date I can tell you there is ONLY ONE health supplement out there that has a formula which properly addresses free radicals, glycation, methylation and inflammation.

It uses a whopping 97 ingredients in order to get the job done.

I’m sure you won’t be surprised to learn that it’s the supplement my family and I have use. I wouldn’t trust my health to any other supplement because quite simply there isn’t another supplement currently out there which takes on each part of the anti aging equation with the specialized nutrients required.

It’s called Total Balance. I use the Men’s Premium version. Use this link if you want to read up more on Total Balance and it’s unique properties. They even have a formula for children! (My niece and nephew use it!)

Total Balance

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If you’ve already read Parts One and Two in this anti aging secrets and nutritional supplements series you’ll understand how the processes that lead to premature aging and the onset of debilitating degenerative disease are all INTERRELATED!

You’ve seen that to be successful, to any real degree, with an anti-aging program you must treat all four of the fundamental components of aging:

Free Radicals
Glycation
Methylation
Inflammation

The bottom line for [tag-tec]nutritional supplements[/tag-tec] marketing themselves as having anti aging benefits and the ability to slow down your aging process, is that they MUST contain the specialized ingredients which can address and tackle not only the free radical problem (which most supplement do reasonably well) but also these other three crippling aging components.

The anti aging secrets presented in parts one and two revealed that when it comes to addressing the first two aging components, free radicals and glycation, virtually all nutritional health supplements and multi ingredient vitamin supplements FAIL to give you either the best of these specialized ingredients (in cases where there are some choices) or NONE AT ALL.

Because almost all supplements are made to a price the manufacturers simply cannot afford to include these expensive rare ingredients!

Anti Aging Secrets – Methylation

So, now I’m going to move on to the third aging factor:-

Methylation

Anti Aging Secrets No 2:

Maintaining and Enhancing Methylation Is A Critical Step In Treating Aging And Disease Including Cancer And Heart Disease!

Have you heard of Methylation before?

Most vitamin supplement consumers won’t have come across it because supplement manufacturers won’t discuss it. Why?

Well that’s an easy answer and I bet you’ve already guessed it. It’s because their products do little to nothing to address Methylation! To mention it would highlight a major weakness in their supplements putting paid to their anti aging and ‘optimal‘ health claims.

Methylation is a biochemical reaction resulting in the attachment of a chemical fragment, called a methyl group, on various substances/molecules in your body, like DNA. DNA methylation is one of the most essential uses of a methylation process however there are many others – in fact there are hundreds of methylation reactions in your body!

So, simply put, methylation is a reaction that provokes changes in your body!

When a a methyl group attaches to some compounds in your body this acts as a catalyst for a reaction to take place such as the ‘turning on of a gene or the activation of an enzyme. (When the methyl group is lost/removed the reaction stops- ie the gene is turned off and the enzyme is deactivated).

Let’s use an example to put this into perspective so that you can understand why we should bother to care or even think about about methylation.

Consider the well known neurotransmitter serotonin.

Receiving a methyl group ‘turns on’ serotonin production leading to appropriate levels of this ‘happy/feel good’ brain chemical. But if your serotonin is not methylated it is turned off and this results in depression. See how methylation can have serious consequences for your health!

Now, people can be an over methylator or they can be an under methylator. In the case of our depression example above let’s say you are an under methylator. If your methylation is increased you may not need to take SSRI’s (Selective Serotonin Reuptake Inhibitors).

This is very important for a person with depression! Further down I’ll explain how supplements can help to increase your methylation.

Please don’t start worrying about whether you’re an over or under methylator. Not everyone is one or the other, there are other groups and you may be in the group that is neither under or over so you’re fine. Statistical analysis by Professor Karl-Peter Pfeiffer from the University of Innsbruck, Austria, suggests 45% are under methylators and 15% are over methylators. That leaves roughly half of the population as neither!

The simplified bottom line for methylation is this:

If your methylation processes are altered, limited or in any way working less than optimally, you are heading for nasty health problems. The effects of under methylation can be seen as premature aging, cancer, heart disease, liver disease and other chronic illness, depression and birth defects. Not to mention the acceleration of your aging process!

So, methylation is incredibly important. It’s a bit like a spark plug in a car- making things turn on and happen. Without methylation you would die in a matter of days!

Anti Aging Secrets – Homocysteine

Now, I’d like to mention homocysteine because the methylation of it is exceptionally crucial to your health.

You’ve probably heard of homocysteine before because of its connection to the most common cause of death in the United States – HEART DISEASE! The medical and health establishments have gone to great lengths over recent years to bring to the general publics attention the importance of keeping their homocysteine levels low.

Homocysteine is a by-product of an important amino acid methionine and is what remains when methionine is used to methylate your proteins and DNA. Homocysteine needs to be methylated and converted back to methionine – it can be toxic if not converted!

How toxic?

Besides heart disease, elevated homocysteine levels are associated with poor circulation, degenerative illnesses (eg Dementia and Alzheimer’s), liver disease, and other severely debilitating conditions!

It is critical to keep your homocysteine levels down!

Anti Aging Secrets – Methylation As Time Goes By

Your body can become methylation-depleted just as it can become depleted with antioxidants or any vitamin or mineral, and with age your methylation process becomes less efficient. This results in DNA damage and a dangerous buildup of homocysteine as well as heightened risk of contracting any of the flow-on degenerative conditions listed above.

So, if you are an under-methylator to begin with or you have become methylation depleted you absolutely need to take action! If you are still young or middle aged then you also need to take action now to balance and possibly enhance your methylation and guard against premature aging and degenerative disease.

The action you need to take is simple! Just supplement your dietary intake with the methylation agents your body needs to successfully complete this task.

Anti Aging Secrets – The Methylation Agents You Must Have In Your Supplement

These 3 groups of compounds are what you want:

• B Vitamins – B6, B12 and Folic Acid
  

• Tri-Methyl-Glycine (TMG) – also known as ‘Betaine’
  

• SAMe (S-Adenosyl-Methionine)

However they are FAR from all equal in their levels of effectiveness as methylating agents!

SAMe stands head and shoulders above the others!

That’s because science and bio-chemistry have long since identified it as the primary methylating substance in the body.

Now, if you think back to parts one and two in this anti aging secrets series you’ll remember how I keep stressing that your aging process results from constituent components which are ALL interrelated.

Free radical damage, (part one), is one of these aging components. So, here’s another example of this interrelationship: free radicals alter methylation patterns!

What’s the big deal with that you may be asking?

Well, it’s these alterations which ‘turn on’ genes.

And that includes CANCER genes!

Anti Aging Secrets No. 3:

SAMe, in it’s role as the primary methylating agent, has the power to reverse damage to methylation patterns caused by free radicals!

So, SAMe is an absolutely vital ingredient that must be in your health supplement if you expect to be successful in your anti aging program. The other methylating agents listed above must of course also be there.

Now, as with parts one and two, I’m going to ask you to go take a look at your supplement bottle label.

In my post about free radicals I asked you to check your label for the most powerful antioxidant L -Glutathione ‘reduced’. Then for glycation you went to check for Carnosine, the only nutrient which can inhibit the formation of those deadly ‘aging’ molecules AGE’s.

I said that because 99% of nutritional vitamin supplements are made to a price, 99% of you won’t find those specialized and critical anti aging ingredients in your supplements because they are simply too expensive for most manufacturers to include.

Well, this time I’m going to ask you to check for SAMe and guess what?

Yes, it’s the same story for this essential ingredient. You won’t find it !

Firstly, because of its super expensive price and secondly, just like L-Glutathione, it is particularly susceptible to damage by stomach acid and so it MUST be used in a pharmaceutical grade enteric coated tablet.

Unless you’re using the supplement that I use, your supplement definitely isn’t enteric coated.

So, SAMe’s not on your supplement label, right? Well, it’s not on mine either!

BUT…… .it will be there by the end of this month. That’s when the 6th Generation version will be released. It already includes all the other effective methylating agents so the inclusion of SAMe will just further enhance it’s existing methylating abilities. This new formula sets a new standard within the supplement industry.

OK, so I’ve now covered three of the four fundamental components of aging (free radicals, glycation, methylation) and we’ve seen the importance of treating all of them in order to produce real anti aging benefits and achieve a life without degenerative disease.

That leaves one more to go.

Look out for my final post in this anti aging secrets series next week where I’ll be discussing inflammation.

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Use this link if you would like to read about the multi ingredient nutritional vitamin supplement I use.

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In Part 1 of this anti aging secrets and nutritional supplements series I looked at the meaning of anti aging in respect of nutritional supplements. This, I stated, was the ability of nutritional health/vitamin supplements to tackle the number 1 most prevalent health concern of the 21 st century – PREMATURE AGING.

Premature aging is responsible for the host of degenerative diseases and illness’ which are inflicting an ever-increasing percentage of the population at younger and younger ages! The stats are climbing year in year out and I’m sure you’re all too aware of this health-devastating trend.

You only have to think about how many people die these days of a disease! That’s NOT how mother nature planned for us to go out!

So, the ‘[tag-tec]anti aging[/tag-tec]‘ capabilities of [tag-ice]nutritional health supplements[/tag-tec] must not only be able to correct [tag-tec]vitamin[/tag-tec]/mineral deficiencies (the simplest common denominator for all of them) and then also be able to help heal degenerative [tag-ice]disease[/tag-ice] which may already be present, but MOST importantly be able to comprehensively address the causes of premature aging in order to slow down and normalize (to some significant degree) the aging process, thereby addressing the spiraling increase in degenerative disease in western diet based societies

I went on to say that virtually all nutritional vitamin supplements FAIL when it comes to addressing premature aging!

Why?

Because there are four primary components of aging and each of these is interdependent on the other three. So, to successfully address premature aging a supplement must contain specialized ingredients which can adequately tackle ALL FOUR.

But….

…. just about any nutritional health supplement you care to examine, including the most well known and ‘so-called’ elite super supplements, can only take on ONE of these four key aging components – which is the reduction of free radicals through the use of antioxidants. (For MANY supplements it’s primarily by way of the cheap, less potent vitamin antioxidants only).

The other 3 critical aging components which are not addressed are Glycation, Methylation and Inflammation because the specialized ingredients needed to deal with them are simply not there!

I then ‘opened up’ for discussion the first ‘anti aging secret’ – the role of free radicals in our aging process and I revealed the names of the most powerful and effective antioxidants which neutralize them (the antioxidants that most supplements can’t afford to include!)

If you haven’t yet read Part 1 and would like to, just follow this link anti aging secrets and nutritional supplements part 1

Today, I will continue on by looking at Glycation and exposing what specialized ingredients MUST be there (but nearly always aren’t) to tackle this SERIOUS health crippling process.

Anti Aging Secrets – Glycation leads to AGES And AGES AGE US!

Oxidative damage to your cellular DNA from excessive free radical production in your body is a SERIOUS problem for your health and wellness but Glycation is far more destructive!

So, if you’re conscientious about good health it’s VERY important that you understand how to protect yourself from glycation.

Glycation is a complex process so bear with me while I first spend a little time explaining it (as simply as I can) before revealing the names of those ‘ANTI GLYCATING INGREDIENTS that I’m sure you want to know asap!

The glycation process revolves around protein molecules in your body and basically alters/damages their configuration so they are unable to function correctly.

This is REALLY BAD NEWS for your health because your various types of proteins have key responsibilities in performing biological activities throughout your body which are critical to your health.

So, in a nutshell, glycation is a (non-enzymatic) reaction through which glucose molecules and chemicals derived from glucose, known as ‘aldehydes’ (collectively we can call them all ‘glycating agents’ for ease of understanding), bind themselves to your intra- and extracellular protein molecules. ie. the protein molecules have become ‘glycated’!

Glycated proteins are no longer ‘free agents’ able to effectively perform their designated biological duties necessary to guard against premature aging.

GLYCATED PROTEINS ARE RELIABLE MARKERS OF DISEASE AND AGING!

The new structures formed by glycated proteins are called AGEs which stands for Advanced Glycation End-products. These are REALLY DANGEROUS molecules when it comes to your health!

When both of the sticky ends of AGEs attach to other neighboring proteins, they create permanent, disabling links.

Anti Aging Secrets: Cross-Linking And YOUR Wrinkles

This process of inappropriate attachment is called ‘cross-linking’. You’ve probably heard this term ‘cross-linking’ before.

Cross-linked chains of AGES decreases the mobility/elasticity of proteins. Cross-linking of the skin protein ‘collagen’ has been shown to be responsible for wrinkling and other age-related changes in skin. So, if you take in a lot of sugar through you diet you’re going to have more glucose molecules floating around inside you and that means more glycation, leading to the collapse of more collagen and so MORE WRINKLES.

AGES normally form and accumulate at a slow and steady rate in everybody (except those with diabetes where the greatly increased availability of glucose leads to a marked increase in their formation earlier in life).

But, AGES do a lot more health-busting damage than just playing a part in creating wrinkles.

They produce poisonous chemicals and toxic by-products as well as stimulating free radical production leading to further glycation – a vicious cycle endures! Glycated proteins increase free radical production 50 fold (over non-glycated proteins).

Remember how I mentioned in Part 1 that each of the 4 primary aging components were interdependent? See how they work together?

Researchers have also implicated glycation to Alzheimer’s disease!

And there’s more! Glycation contributes to HEART DISEASE. It thickens artery walls and clinical evidence suggests that AGEs are important components in the formation of potentially lethal atherosclerotic plaque – that’s the stuff that can build up to impede and block blood flow in your arteries.

So, you’ve no doubt got the picture by now of how destructive glycation is to your health. You absolutely need to take action to limit the amount of glycation and formation of AGES in you body. This is a VITAL STEP in slowing down and normalizing your aging process.

What to do!

1. GREATLY reduce the intake of sugar in your diet. Learn the ‘hidden’ sugar content of what you are eating. Avoid simple carbohydrates!

 

2. Inactivate the glycating agents (aldehydes) before they can bind to your proteins

 

3. Prevent a glycated protein from binding to another ‘free’ protein and creating a cross-linked chain

You’re wondering what to do for steps 2 and 3, right?

Well, you can achieve that through ‘Carnosinylation’!

Huh?

A clever and powerful nutrient called Carnosine (an amino acid) is capable of defending your body’s proteins against glycation. The process by which carnosine does this is called carnosinylation.

Inhibiting The Formation Of AGES Is An ESSENTIAL Part Of Any SUCCESSFUL Anti Aging And Life Extension Program!

Here’s what carnosine actually does!

1. It can bind itself to glycating agents and NEUTRALIZE them

2. And it can put a shield around a protein molecule which already has a glycating agent attached. This protects and prevents it from cross-linking with another protein

NO OTHER NUTRIENT CAN DO THIS!

Oh, and carnosine stops the oxidative damage of free radicals!

If you go and check your supplement label I bet you won’t find carnosine listed there. That’s because it’s a very expensive ingredient for nutritional supplement manufacturers to purchase. They simply can’t afford to include it. So, once again we come back to the greatest limitation in the formulation (and effectiveness) of nutritional vitamin supplements – that they are made to a price!

This is why supplement companies (deliberately) fail to mention glycation on their websites or in their product marketing presentations. They don’t want to highlight a major weakness in their product!

Anti Aging Secrets: How Much Carnosine?

“Like so many nutrients there is no real evidence to support the premise ‘more is better’“

The generally accepted effective dose rate is 50 – 150 mg daily!

The multi ingredient health supplement my family and I have used for the past 7 years is called Total Balance and it includes a generous dose of 100 mg of carnosine in a daily dose. (That’s one of the main reasons I originally opted to use it.)

Use these links to take a look at total balance mens plus or total balance womens plus

Or follow this link if you’d like to read my in-depth review of total balance (It’s a loooong one!)

Now, some of you may be thinking right about now about racing out to buy a bottle of isolated carnosine. Don’t do that.

Carnosine, like most specialty nutrients, works FAR more effectively when combined with other compatible ingredients (that’s why you need a professional grade supplement formulated by a bio-scientist or chemist because only they know what nutrients are compatible with one another at the molecular level in your body to synergize enhanced efficacy).

Supplements put together by physicians and worse still by marketers, don’t even come close to making the grade!

And , as you’ve discovered, glycation is only one of the four (interdependent) primary components of aging. There’s not much point in addressing only glycation at the expense of the other 3.

Anti aging secrets special note:

There are currently some really promising experimental drugs being tested to fight AGES – but sorry you’ll have to wait a while. None are yet commercially available. If and when any do become available I’ll be sure to make a post about it.

In the next part of this anti aging secrets series I’ll discuss the third aging component, METHYLATION, and give you a heads-up on the special methylation agents you need in your vitamin supplement to combat it.

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